Parkin and Its Substrates

13 July 2001

journal article
editorial
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 293 (5528) , 224-225
https://doi.org/10.1126/science.1063286

Abstract

What causes the selective degeneration of nigrostriatal dopaminergic neurons in the brains of Parkinson9s disease patients? As Haass and Kahle explain in their Perspective, a clue comes from new work showing that two proteins implicated in PD (parkin and a-synuclein) normally interact in healthy neurons ( Shimura et al.). The Perspective authors speculate that defective targeting of a-synuclein for degradation by parkin results in accumulation of toxic a-synuclein aggregates that selectively kill dopaminergic neurons.

Keywords

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