Decline in Antibiotic Enzyme Activity of Neutrophils Is a Prognostic Factor for Infections in Patients with Myelodysplastic Syndrome
Open Access
- 15 November 2000
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 31 (5) , 1292-1295
- https://doi.org/10.1086/317470
Abstract
We used flow cytometry to measure the activities of cathepsin G and elastase. The activity of elastase in neutrophils from patients with myelodysplastic syndrome (MDS) was significantly lower than that in neutrophils from the control group (P < .001). Patients with low elastase activity were significantly susceptible to infection (P < .05). Our study suggests that analyzing antibacterial enzymes is useful in evaluating the prognosis of patients with MDS.Keywords
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