THE EFFECT OF EXPERIMENTAL HYPERTHYROIDISM ON THE MOVEMENTS OF THE EMPTY STOMACH

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Abstract
[long dash]Dogs (5) were used throughout the investigation (9 mos.). Of the 5 animals originally used, 2 were again run on a much higher dosage after an interim of 5 mo., during which time they were used for other work. A small dosage of desiccated thyroid sufficient to produce the syndrome of hyperthyroidism in dogs causes an increase in the height of hunger contractions. There seem to be 2 effects produced by feeding desiccated thyroid: one in which a hunger producing constituent causes an increase in hunger and the other in which a toxic, depressant constituent may or may not overbalance the former, depending upon the degree of tolerance to the latter that the individual dog may develop; or, it may be that these are one and the same substance, its hunger effects depending upon the tolerance developed by the individual dog. In the 15 gm. dosage, the increase in hunger effect seems to overbalance the toxic effect although the same result might have been noted in the 5 gm. dogs had they been run long enough.

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