Fluorescence of Intravenously Administered Rose Bengal Appears Only in Hepatic Polygonal Cells
- 1 March 1949
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 70 (3) , 556-558
- https://doi.org/10.3181/00379727-70-16991
Abstract
Aqueous solns. (1-2%) of tetra-iodotetrachlor fluorescein (Rose Bengal) exhibit orange fluorescence in u.-v. light (3150-3650 A). Liver biopsies obtained 1-15 min. after intraven. injn. of such solns. into rabbits and examined by u.-v. microscopy, show the fluorescence to be located in the hepatic polygonal cells, but not in the Kupffer cells. Two human liver biopsies following similar injns. showed the same picture. Since other evidence indicates that Rose Bengal and Bromsulfalein are handled by similar hepatic mechanisms, it is suggested that both dyes are removed by and stored in hepatic polygonal cells, not Kupffer cells.Keywords
This publication has 1 reference indexed in Scilit:
- THE ESTIMATION OF HEPATIC BLOOD FLOW IN MANJournal of Clinical Investigation, 1945