Stability of Phenytoin in Blood Collected in Vacuum Blood Collection Tubes
- 1 January 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 12 (1) , 85-89
- https://doi.org/10.1097/00007691-199001000-00016
Abstract
The stability of phenytoin in blood collected in plain and serum separator tubes (SSTs) was investigated under stimulated storage and transport conditions. The drug was generally more stable in plain collection tubes than in SSTs. No degradation occurred in plain red-top tubes or in refrigerated SSTs, but clinically significant degradation was present in SSTs stored at room temperature (25.degree.C) and at elevated temperature (32.degree.C) 24 h after collection. The mean loss was 17.9% at 25.degree.C and 25.9% at 32.degree.C. It is recommended that if blood is to be transported or stored in SSTs, the samples be refrigerated unless assay can be performed within 8 h.This publication has 2 references indexed in Scilit:
- Stability of Drug Concentrations in Plasma Stored in Serum Separator Blood Collection TubesTherapeutic Drug Monitoring, 1988
- Reduced Serum Tricyclic Levels Due to Gel SeparatorsJournal of Clinical Psychopharmacology, 1987