Promoter-specific inhibition of transcription by antibiotics which act on DNA gyrase
- 1 October 1978
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 275 (5679) , 420-423
- https://doi.org/10.1038/275420a0
Abstract
Nalidixic acid, novobiocin and coumermycin specifically inhibit phage promoter-dependent transcription of the trp operon in Φ80ptrp but not transcription from the authentic trp promoter. The nalidixic acid inhibition is not observed in an E. coli strain containing a nalAr mutation. These results indicate that DNA gyrase is involved in transcription.Keywords
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