CHANGES IN BLOOD FAT PRODUCED BY FASTING, PHLORHIZIN AND PANCREATECTOMY

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Abstract
[long dash]On 8 fasted, 17 phlorhizinized, and 24 depancreatized dogs, 144 observations were made on the blood of the organs. Most striking were the results obtained on the liver, indicating that that organ removes fat from the blood of fasting animals. The liver of phlorhizinized dogs removed fat from the blood until the 5th day, when the accumulated fat was liberated. The liver of depancreatized dogs, on the other hand, added fat to the blood except for a short period approximately 12 hrs. post-operative, when that foodstuff was absorbed. These phenomena may be due to the more rapid mobilization of the fat depots of the depancreatized animals. An increased concentration of fat in the portal and femoral vein, which is apt to appear in the dogs fasted 2 or 3 days, indicates a mobilization of the fat depots. On the other hand, observations obtained after more prolonged fasting in the phlorhizinized and depancreatized dogs more often revealed a removal of fat from the blood passing muscle and viscera. The kidney of phlorhizinized or depancreatized dogs absorbed fat from the blood and in amounts too great for oxidation, possibly indicating an excretion, but more probably a storage, of fat in that organ.

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