Cutaneous manifestations of angioimmunoblastic lymphadenopathy

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Abstract
Of 22 patients with angioimmunoblastic lymphadenopathy seen at the Mayo Clinic [Rochester, Minnesota, USA] from 1962-1978, six had associated cutaneous lesions exhibiting characteristic histologic features at biopsy. Clinically, 3 patients had generalized maculopapular eruptions, two had generalized petechiae and one had generalized erythroderma and petechiae located on the extremities. In each patient the eruption occurred concurrently with or prior to the onset of generalized lymphadenopathy. Pathologically, all skin biopsy specimens showed lymphohistiocytic vasculitis, vascular proliferation, extravasated red blood cells and occasional scattered mature plasma cells. These histologic findings were similar to but less intensive than those noted on biopsy specimens of involved lymph nodes. Although suggestive of angioimmunoblastic lymphadenopathy, histologic findings of skin lesions do not appear to be diagnostic, thus stressing the difficulty of defining the syndrome in the absence of lymph node biopsy.

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