PORTAL VERSUS SYSTEMIC TRANSPLANTATION OF DISPERSED NEONATAL PANCREAS
- 1 November 1977
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 24 (5) , 333-337
- https://doi.org/10.1097/00007890-197711000-00004
Abstract
It is not known whether the advantage of the portal vein as a transplant site for islet transplantation is caused by the immediate availability of a blood supply or by the localization of the islets in the portal circulation. We transplanted minimal quantities of islet tissue from neonatal rat donors to isogeneic adult rats with streptozotocin-induced diabetes. Transplants were performed to three sites, i.p., portal vein, and systemic vein (i.v.). When four neonatal donors were used for each recipient there were no i.p. cures but 90% i.v. and 100% portal vein cures, which suggests that access to a blood supply is important. As the amount of tissue transplanted was decreased, there were significantly more cures with the portal vein route, which suggests that localization of the islets in the portal circulation is also important to graft survival.This publication has 4 references indexed in Scilit:
- ISLET TRANSPLANTATION - CRITICAL PERIOD OF DONOR ISCHEMIA IN NEONATAL RATS1977
- Metabolic and morphologic studies in intraportal-islet-transplanted ratsDiabetes, 1976
- Comparison of peripheral and portal routes of insulin infusion by a computer-controlled insulin infusion system (artificial endocrine pancreas)Diabetes, 1976
- MINIMAL COLLAGENASE DIGESTION - AMELIORATION OF DIABETES IN RAT WITH TRANSPLANTATION OF ONE DISPERSED NEONATAL PANCREAS1976