THE INFLUENCE OF A DIET WITH A HIGH PROTEIN CONTENT UPON THE APPETITE AND DEPOSITION OF FAT

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Abstract
When the carbohydrate in an adequate synthetic diet is replaced with protein (casein) the appetite of albino rats is definitely decreased; after a time they show marked differences in body wt. and fat content, those on high protein diet having less deposit fat. The reduced appetite on a high protein diet is due to the protein content and not to lack of carbohydrate as such; replacement of the carbohydrate calories with fat does not result in the same marked reduction in the appetite and body fat. Protein Zn insulin produces increased appetite with a diet high in carbohydrate but a much smaller increase with an isoglucogenic diet high in protein. Since protamine Zn insulin appears to increase the appetite by reducing the blood sugar level a high protein, carbohydrate free diet may decrease the appetite by better maintaining the blood sugar level, glucose from protein being formed slowly and therefore more evenly available than when fed as carbohydrate.

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