Mechanisms of acetaminophen oxidation to N-acetyl-P-benzoquinone imine by horseradish peroxidase and cytochrome P-450.
Open Access
- 4 January 1987
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 262 (3) , 966-973
- https://doi.org/10.1016/s0021-9258(19)75735-4
Abstract
No abstract availableThis publication has 27 references indexed in Scilit:
- Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavoneBiochemistry, 1982
- Superoxide and hydrogen peroxide production and NADPH oxidation stimulated by nitrofurantoin in lung microsomes: Possible implications for toxicityLife Sciences, 1979
- Hydroperoxide‐Metabolizing Systems in Rat LiverEuropean Journal of Biochemistry, 1975
- Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450Biochemical and Biophysical Research Communications, 1974
- Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophenLife Sciences, 1974
- Microsomal-catalyzed hydroperoxide-dependent C-oxidation of aminesBiochemical and Biophysical Research Communications, 1973
- HEPATIC DAMAGE AND DEATH FROM OVERDOSE OF PARACETAMOLThe Lancet, 1973
- PLASMA-PARACETAMOL HALF-LIFE AND HEPATIC NECROSIS IN PATIENTS WITH PARACETAMOL OVERDOSAGEThe Lancet, 1971
- Acute liver necrosis following overdose of paracetamol.BMJ, 1966
- Chemical Nature of the Secondary Hydrogen Peroxide Compound Formed by Cytochrome-C Peroxidase and Horseradish PeroxidaseNature, 1952