Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
- 1 November 2004
- journal article
- research article
- Published by Elsevier in Cancer Cell
- Vol. 6 (5) , 485-495
- https://doi.org/10.1016/j.ccr.2004.09.026
Abstract
No abstract availableKeywords
This publication has 48 references indexed in Scilit:
- Hypoxia-Induced Gene Expression Occurs Solely through the Action of Hypoxia-Inducible Factor 1α (HIF-1α): Role of Cytoplasmic Trapping of HIF-2αMolecular and Cellular Biology, 2003
- Regulation of angiogenesis by hypoxia: role of the HIF systemNature Medicine, 2003
- The biology of VEGF and its receptorsNature Medicine, 2003
- Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in VivoDevelopmental Biology, 2001
- Cutaneous Wound HealingNew England Journal of Medicine, 1999
- Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor GenesJournal of Biological Chemistry, 1997
- Patterns and Emerging Mechanisms of the Angiogenic Switch during TumorigenesisPublished by Elsevier ,1996
- Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceNature, 1995
- Endothelial cell tolerance to hypoxia. Potential role of purine nucleotide phosphates.Journal of Clinical Investigation, 1995
- Tumor Angiogenesis: Therapeutic ImplicationsNew England Journal of Medicine, 1971