Biocatalysis in Organic Synthesis 7. Enantioselective Transesterification Catalyzed by an Acylase: Remarkable Influence of Remote Substitution and the Nature of the Solvent on the Selectivity1

Abstract
Acylase I from Aspergillus species catalyzes the reaction of transesterification between vinyl acetate and racemic derivatives of 2-(hydroxymethyl)piperidine. It has been found that the enantioselectivity of the reaction depends on the solvent. Also it has been observed that remote substituents have a great influence on the enantioselectivity.

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