Erythrocyte pyrimidine 5?-nucleotidase activity in workers exposed to lead, mercury or cadmium
- 1 April 1985
- journal article
- research article
- Published by Springer Nature in Internationales Archiv für Arbeitsmedizin
- Vol. 55 (3) , 247-252
- https://doi.org/10.1007/bf00383757
Abstract
The erythrocyte pyrimidine 5′-nucleotidase activity (P5N) was measured in workers exposed to lead, cadmium or inorganic mercury and the effect of lead on this enzyme activity was compared with that on the classical biological parameters (ALAD, ZPP, ALAU), reflecting the interference of this metal with the heme biosynthesis pathway. P5N is inhibited by lead but not by cadmium and mercury. The correlation coefficient between log P5N and lead in blood (PbB) amount to 0.79 (n = 278; PbB ranging from 4.9 to 73.5 μg/100 ml). The response of P5N to lead closely parallels that of ALAD.Keywords
This publication has 13 references indexed in Scilit:
- In vitro effects of lead, mercury and cadmium on the enzymic activity of red-blood cell pyrimidine 5'-nucleotidaseToxicology Letters, 1984
- Low level lead and inhibition of erythrocyte pyrimidine nucleotidaseEnvironmental Research, 1978
- Red-cell pyrimidine 5′-nucleotidase and lead poisoningClinica Chimica Acta; International Journal of Clinical Chemistry, 1978
- Placental transfer of lead, mercury, cadmium, and carbon monoxide in womenEnvironmental Research, 1978
- Lead poisoning. Further observations on erythrocyte pyrimidine-nucleotidase deficiency and intracellular accumulation of pyrimidine nucleotides.Journal of Clinical Investigation, 1977
- Lead poisoning: association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidines.Journal of Clinical Investigation, 1976
- Effects of low-level lead exposure on pyrimidine 5'-nucleotidase and other erythrocyte enzymes. Possible role of pyrimidine 5'-nucleotidase in the pathogenesis of lead-induced anemia.Journal of Clinical Investigation, 1975
- Response of free erythrocyte porphyrin and urinary ? -aminolevulinic acid in men and women moderately exposed to leadInternationales Archiv für Arbeitsmedizin, 1975
- Hereditary Hemolytic Anemia with Human Erythrocyte Pyrimidine 5′-Nucleotidase DeficiencyJournal of Clinical Investigation, 1974
- Automated analysis of delta-aminolaevulinic acid in urineClinica Chimica Acta; International Journal of Clinical Chemistry, 1972