On the purine metabolism of the Dalmatian coach hound

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Abstract
2 Dalmatian puppies were subjected to metabolic expts. on synthetic diets containing single proteins to contrast the excretion of uric acid and allantoin with the dietary content of particular amino acids. The uricolytic index is characteristic of the diet and of the individual dog, varying from 29-90. The evidence for a particular precursor in purine synthesis is not conclusive; cystine is eliminated. Guanine, xanthine, uric and nucleic acids administered by capsule increased the output of allantoin and of urea, raising the uricolytic index. The excretion of uric acid was notably constant suggesting an endogenous metabolite. It was found to be 30-40 mgm. per kgm. body wt., and was more characteristic of the Dalmatian than the uricolytic index.

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