Glycosomes: parasites and the divergence of peroxisomal purpose
Open Access
- 28 June 2004
- journal article
- review article
- Published by Wiley in Molecular Microbiology
- Vol. 53 (3) , 717-724
- https://doi.org/10.1111/j.1365-2958.2004.04203.x
Abstract
Peroxisomes are membrane‐bounded organelles that compartmentalize a variety of metabolic functions. Perhaps the most divergent peroxisomes known are the glycosomes of trypanosomes and their relatives. The glycolytic pathway of these organisms resides within the glycosome. The development of robust molecular genetic and proteomic approaches coupled with the completion of the genome sequence of the pathogens Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major provides an opportunity to determine the complement of proteins within the glycosome and the function of compartmentation. Studies now suggest that regulation of glycolysis is a strong driving force for maintenance of the glycosome.Keywords
This publication has 37 references indexed in Scilit:
- Peroxisomal Targeting as a Tool for Assaying Protein-Protein Interactions in the Living CellPublished by Elsevier ,2004
- Ether Phospholipids and Glycosylinositolphospholipids Are Not Required for Amastigote Virulence or for Inhibition of Macrophage Activation by Leishmania majorJournal of Biological Chemistry, 2003
- A Second Class of Peroxidases Linked to the Trypanothione MetabolismJournal of Biological Chemistry, 2003
- Mitochondrial Substrate Level Phosphorylation Is Essential for Growth of Procyclic Trypanosoma bruceiJournal of Biological Chemistry, 2002
- Molecular Characterization of the First Two Enzymes of the Pentose-phosphate Pathway of Trypanosoma bruceiPublished by Elsevier ,2000
- Novel organization and sequences of five genes encoding all six enzymes for de novo pyrimidine biosynthesis in Trypanosoma cruziJournal of Molecular Biology, 1999
- Identification of 2-enoyl coenzyme A hydratase and NADP+-dependent 3-hydroxyacyl-CoA dehydrogenase activity in glycosomes of procyclic Trypanosoma bruceiMolecular and Biochemical Parasitology, 1996
- Subcellular distribution of trypanothione reductase in bloodstream and procyclic forms of Trypanosoma bruceiMolecular and Biochemical Parasitology, 1991
- Localization of the initial steps in alkoxyphospholipid biosynthesis in glycosomes (microbodies) of Trypanosoma bruceiFEBS Letters, 1984
- A comparative study of Leishmania mexicana amastigotes and promastigotes, enzyme activities and subcellular locationsMolecular and Biochemical Parasitology, 1982