Elimination in Human Feces of Infectious Hepatitis Virus Parenterally Introduced.

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Abstract
It is known that patients with naturally acquired or experimentally induced (by feeding) infectious hepatitis have virus in the blood and feces during the actute phase of disease. An attempt was made to determine if this virus is also eliminated in the feces during the acute phase of infectious hepatitis experimentally induced in human volunteers by parenteral inoculation. Pooled specimens of feces as well as serum, collected from 8 such subjects during the acute phase of their disease were infectious, when administered to other human volunteers producing infectious hepatitis with jaundice in 5 out of 6 subjects with incubation periods ranging from 15-28 days. This recovery of virus from the stool of patients with infectious hepatitis induced by parenteral inoculation constitutes an apparent difference between this condition and homologous serum jaundice in which the etiologic agent has not been recovered from the stool up to the present time.

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