In vitro assessment of the toxicity of metal compounds
- 1 December 1982
- journal article
- Published by Springer Nature in Biological Trace Element Research
- Vol. 4 (4) , 319-330
- https://doi.org/10.1007/bf02786545
Abstract
A review of in vitro mutagenesis assessment of metal compounds in mammalian and nonmammalian test systems has been compiled. Prokaryotic assays are ineffective or inconsistent in their detection of most metals as mutagens, with the notable exception of hexavalent chromium. Mammalian assay systems appear to be similarly inappropriate for the screening of metal compounds based upon the limited number of studies that have employed those compounds having known carcinogenic activity. Although of limited value as screening tests for the detection of potentially carcinogenic metal compounds, the well-characterized in vitro mutagenesis systems may prove to be of significant value as a means to elucidate mechanisms of metal genotoxicity.Keywords
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