Effects of anoxia on K and Ca currents in isolated guinea pig cardiocytes
- 1 April 1990
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 416 (1-2) , 207-209
- https://doi.org/10.1007/bf00370244
Abstract
Whole cell currents were measured in isolated cardiocytes of guinea pig under anoxic conditions (pO2 90%) to their complete disappearance in 2 to 4 (mean 2.87, n=15) seconds. Ca currents were not affected at the time when the first extra outward currents occurred. It is concluded that (i) the anoxia-induced outward current is carried by K+ ions probably through KATP channels which open at intracellular ATP concentrations below 1 mmol/l (Noma and Shibasaki 1985) and (ii) this degree of ATP depletion does not affect normal Ca channel function.Keywords
This publication has 14 references indexed in Scilit:
- Glibenclamide inhibition of ATP-sensitive K+ channels and ischemia-induced K+ accumulation in the mammalian heartPflügers Archiv - European Journal of Physiology, 1989
- Membrane current through adenosine‐triphosphate‐regulated potassium channels in guinea‐pig ventricular cells.The Journal of Physiology, 1985
- Direct observation of the "oxygen paradox" in single rat ventricular myocytes.Circulation Research, 1985
- Ca-tolerant guinea-pig ventricular myocytes as isolated by pronase in the presence of 250 µM free calciumPublished by Springer Nature ,1984
- The effect of cyanide on the K-current in guinea-pig ventricular myocytesPublished by Springer Nature ,1984
- ATP-regulated K+ channels in cardiac muscleNature, 1983
- Ionic currents during hypoxia in voltage-clamped cat ventricular muscle.Circulation Research, 1980
- Hypoxia increases potassium efflux from mammalian myocardiumCellular and Molecular Life Sciences, 1976
- Metabolism and the electrical activity of anoxic ventricular muscleThe Journal of Physiology, 1973
- Der Aktionsstrom der Myokardfaser im SauerstoffmangelPflügers Archiv - European Journal of Physiology, 1954