Antigenic Properties of Experimental Leukemias. I. Serological Studies In Vitro With Spontaneous and Radiation-Induced Leuke-mias2

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Abstract
Antisera prepared in C57BL/6 mice against several spontaneous or radiation-induced leukemias of strain A, or against a radiation-induced (C57BL/6 × A)F1 leukemia, were cytotoxic in vitro for the cells of 14 radiation-induced C57BL/6 leukemias and 1 C57BL/6 leukemia induced by urethan. These antisera were not cytotoxic for any of the normal C57BL/6 tissues studied. Specific cytotoxic activity was removed by absorption with those C57BL/6 leukemias that are sensitive in the cytotoxic test, but not by normal C57BL/6 tissue. Cytotoxic activity was removed by absorption with normal thymus of strains A, (C57BL/6 × A)F1, and C58, but not with normal thymus of several other strains, including C57-BL/6. Normal strain A tissues, other than thymus, did not absorb specific cytotoxic activity. These serological data indicate the presence of a common antigenic component in certain C57-BL/6 leukemias and in the normal thymus and leukemias of strains A and C58 origin. In conformity with presence of the antigen in the thymus of normal strain A mice, cytotoxic activity against strain A leukemias was not demonstrable in the sera of strain Amice immunized against cross-reacting C57-BL/6 leukemias.

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