Effects of chlorpromazine on exploration and habituation in the rat

Open Access

1 October 1973

journal article
Published by Wiley in British Journal of Pharmacology

Vol. 49 (2) , 303-310
https://doi.org/10.1111/j.1476-5381.1973.tb08376.x

Abstract

Summary: The effects of chlorpromazine, 2 and 4 mg/kg, on exploration were investigated under two independent influences—food deprivation and time of day. Rats had three 3‐minute trials in a hole‐board apparatus; hole‐investigation (head‐dips) and general motor activity were recorded. On trial 1 chlorpromazine reduced exploration to half the control level, but on trial 3 it had no effect on motor activity or head‐dips. General activity habituated from trial 1 to 3 in all groups, but some of the drug groups did not show significant habituation of head‐dips, due to the low level of responding on trial 1.

Keywords

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