Thyroid-Catecholamine Interrelations

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Abstract
Thyroid hormones and the catecholamines interact synergistically, so that the effects of the catecholamines are exaggerated by thyroid hormone excess and attenuated by thyroid hormone deficiency. Partial or total general adrenergic blockade reduces the hemodynamic, neuromuscular and metabolic effects of thyroid hormone excess, without entirely abolishing them. Differential blockade of a and B adrenergic receptors has relatively less effect upon hyperthyroidism, suggesting that both types of receptors are concerned in manifestation of thyroid hormone excess. The locus for synergistic interaction of these hormones may be the adrenergic receptor site.