Influence of Food on the Bioavailability of Trental® (Pentoxifylline) in Man

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Abstract
Pentoxifylline is an investigational drug shown to improve impaired blood flow in diseased microvasculature. The present study objective was to determine the influence of a single test meal on the bioavailability of pentoxifylline. Single 400 mg oral capsule doses of pentoxifylline were administered to 16 healthy adult male volunteers in a complete crossover design in which the subjects received the drug after fasting overnight or 15 minutes following a standard breakfast. The plasma concentrations of pentoxifylline and its major metabolite were determined as a function of time using a gas chromatographic procedure. The AUC values for both parent drug and metabolite for 0 to 10 hours showed no significant difference due to ingestion of food. A significant decrease in peak plasma concentration (p < .05) was shown for parent drug and metabolite when administered with food. The time-to-peak concentration was significantly delayed (p < .001) when the drug was administered with food. Food administered concomitantly with pentoxifylline delays absorption and lowers peak plasma concentration, although the extent of absorption is not different than when the drug is administered on an empty stomach.

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