Abstract
More than 30,000 individuals have been investigated in the continuous screening and intervention study in Malmö. Large subsamples of individuals with different levels of serum γ-glutamyltransferase (GGT) have been characterized and followed up; GGT has proved to be a useful and simple tool in identifying and treating heavy drinkers and monitoring their outcome. In the intervention study, counseling and repeated feedback of GGT results in a group of middle-aged heavy drinkers led to a significant reduction in sick absence, hospitalization, and mortality compared with those in a control group over a period of 6 to 8 years. At follow-up, about 15% of middle-aged men in the general population had serious alcohol problems. Assessment and treatment of heavy drinkers within general medicine would provide a very considerable impact on the total problem of alcohol-related disease.

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