THE INVESTIGATION OF RADIOPHARMACEUTICAL COMPONENTS BY FAST ATOM BOMBARDMENT MASS-SPECTROMETRY - THE IDENTIFICATION OF TC-HIDA AND THE EPIMERS OF TC-CO2DADS
The nature of 2 Tc-labeled radiopharmaceutical components was established by fast-atom-bombardment mass spectrometry (FABMS) in combination with carrier-added (CA) and no-carrier-added (NCA) reversed-phase high-pressure liquid chromatography (HPLC). Negative-ion FABMS was used to determine that the epimers of Tc-CO2-DADS are the oxo[N,N''-(1-carboxyethylene)-bis-(2-mercaptoacetimido)]technetate(V) ions; positive-ion FABMS showed that Tc-HIDA is bis[N-(2,6-dimethylphenyl-carbamoylmethyliminodiaceto)]technetate(II).