Expanding insights of mitochondrial dysfunction in Parkinson's disease
Top Cited Papers
- 1 March 2006
- journal article
- review article
- Published by Springer Nature in Nature Reviews Neuroscience
- Vol. 7 (3) , 207-219
- https://doi.org/10.1038/nrn1868
Abstract
The quest to disentangle the aetiopathogenesis of Parkinson's disease has been heavily influenced by the genes associated with the disease. The alpha-synuclein-centric theory of protein aggregation with the adjunct of parkin-driven proteasome deregulation has, in recent years, been complemented by the discovery and increasing knowledge of the functions of DJ1, PINK1 and OMI/HTRA2, which are all associated with the mitochondria and have been implicated in cellular protection against oxidative damage. We critically review how these genes fit into and enhance our understanding of the role of mitochondrial dysfunction in Parkinson's disease, and consider how oxidative stress might be a potential unifying factor in the aetiopathogenesis of the disease.Keywords
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