PROTECTION OF ISCHEMIC MYOCARDIUM - ULTRASTRUCTURAL, ENZYMATIC, AND FUNCTIONAL ASSESSMENT OF EFFICACY OF VARIOUS CARDIOPLEGIC INFUSATES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 76  (1) , 2-15
Abstract
The increasing use of cardioplegic protective infusates for reducing ischemic tissue injury requires that all infusates be carefully assessed for any protective or damaging properties. Ultrastructural, enzymatic and functional assessments of the efficacy of 3 infusates (Bretschneider, Kirsch and St. Thomas'' Hospital) are described in a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest. There is a close concordance of results as assessed by the 3 total different indices of tissue damage. In the rat heart model, the St. Thomas'' Hospital solution is an effective protective agent under all conditions studied, but the Bretschneider solution is effective only under hypothermic conditions and the Kirsch solution is ineffective under all conditions studied and may exacerbate tissue injury. The potentially damaging effects of Ca-free myocardial infusates may be due to their induction of a Ca paradox.

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