A Lymphotoxin-β-Specific Receptor
- 29 April 1994
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 264 (5159) , 707-710
- https://doi.org/10.1126/science.8171323
Abstract
Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. The cell surface form of LT-alpha is assembled during biosynthesis as a heteromeric complex with lymphotoxin-beta (LT-beta), a type II transmembrane protein that is another member of the TNF ligand family. Secreted LT-alpha is a homotrimer that binds to distinct TNF receptors of 60 and 80 kilodaltons; however, these receptors do not recognize the major cell surface LT-alpha-LT-beta complex. A receptor specific for human LT-beta was identified, which suggests that cell surface LT may have functions that are distinct from those of secreted LT-alpha.Keywords
This publication has 37 references indexed in Scilit:
- Abnormal Development of Peripheral Lymphoid Organs in Mice Deficient in LymphotoxinScience, 1994
- A novel domain within the 55 kd TNF receptor signals cell deathCell, 1993
- Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenesNature, 1993
- Biochemical characterization of the extracellular domain of the 75-kilodalton tumor necrosis factor receptorBiochemistry, 1993
- Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosisNature, 1992
- A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral ProteinsScience, 1990
- Molecular cloning and expression of a receptor for human tumor necrosis factorCell, 1990
- Molecular cloning and expression of the human 55 kd tumor necrosis factor receptorCell, 1990
- A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNFCell, 1988
- Production and characterization of monoclonal antibodies against recombinant human tumor necrosis factor/cachectinBiochemical and Biophysical Research Communications, 1986