Single-dose vaccination of mice against experimental infection with Trypanosoma (Trypanozoon) brucei

Publisher Website
Google Scholar
Abstract
Summary Protective immunity against intraperitoneal challenge with Trypanosoma brucei of homologous antigenic type was produced in mice by the induction of infection and its cure with a drug. It was also produced by single doses of a variety of vaccines, including killed organisms, released antigens and formalinised whole infected blood or plasma administered in the form of crude, water-in-oil or multiple emulsions by the subcutaneous or intravenous route. Vaccines of mixed antigenic types protected mice against challenge with trypanosomes corresponding to each of its components either severally or together, but cross protection between antigenic types was not demonstrated.

This publication has 0 references indexed in Scilit: