A Double-blind Controlled Comparison of Generic and Trade-Name Topical Steroids Using the Vasoconstriction Assay

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Abstract
• Six generic formulations of five topical steroids were compared for bioequivalence with their trade-name counterparts using an in vivo vasoconstriction assay. Two of six generic formulations were found to show significantly less vasoconstriction than the respective trade-name topical steroids. The issue of generic equivalence of topical steroids is discussed, with particular emphasis on the vagaries of the vasoconstriction assay. (Arch Dermatol. 1991;127:197-201)