INACTIVATED POLIOVACCINE: ADVERSE REACTIONS AND ANTIBODY RESPONSES

Publisher Website
Google Scholar
Abstract
Adverse reactions and antibody responses after inactivated poliovaccine were studied in 380 children. Fever reaction (.gtoreq. 37.5.degree. C rectally) was recorded in 14% of children after the 1st poliovirus vaccination and in 19% after the 2nd. Restlessness was reported in 15% and 14% of the children. Fever reaction exceeding 38.5.degree. C was seen in 5% of the vaccines. Before the 1st vaccination at the age of 6 mo. 29% of the 48 children had antibodies against poliovirus types 1 and 2 and 43% against type 3. The 1st vaccination induced no significant changes in antibody titers. After the 2nd vaccination antibody responses were low and 35%, 9% and 35% remained seronegative to types 1, 2 and 3, respectively. After the 3rd vaccination at the age of 2 yr the respective geometric mean titers were 1:67, 1:335 and 1:48. No measurable antibodies were found to type 1 in 23%, to type 2 in 2% and to type 3 in 10%. Only 1 child was triple negative. All seronegative children were revaccinated and in all vaccinees a seroconversion occurred 2 wk after the booster dose. The combination of inactivated poliovaccine to DPT (diphtheria, tetanus, pertussis) vaccine induced no significant change in poliovirus antibodies or in adverse reactions.