Effect of Estrogens on Malic Dehydrogenase of Rat Liver.

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Abstract
The inhibitory action of one androgenic and 7 estrogenic compounds was tested on liver malic dehydrogenase in vitro. Stilbestrol and ben-zestrol estrogens were effective inhibitors, but little inhibition occurred when the phenolic groups of the stilbestrol type compounds were replaced by oxyacetate groups as for example in disodium 3,4-diphenylhexane-p,p''-dioxyacetate. In addition Na androsterone sulphate which contained an alcoholic in place of a phenolic group showed very little inhibitory action. The presence of phenolic groups were necessary for inhibition to take place. It was concluded also from inhibitor studies with diethylstilbestrol, in which brilliant cresyl blue was substituted for cytochrome c, that diethylstilbestrol exerted its inhibitory action on cytochrome oxidase rather than on malic dehydrogenase.