Cigarette Smoking and the Risk of Mucinous and Nonmucinous Epithelial Ovarian Cancer

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Abstract
The association between cigarette smoking and ovarian cancer may vary according to the histologic type of tumor. We examined cigarette smoking as a risk factor for both mucinous and nonmucinous tumors in a population-based case-control study comparing 767 incident cases of epithelial ovarian cancer with 1,367 community controls frequency matched to cases by age and race. Smoking was associated with mucinous tumors (odds ratio [OR] = 1.9; 95% confidence interval [CI] = 1.3–2.9) but not with nonmucinous tumors (OR = 1.1; CI = 0.9–1.3). Furthermore, the odds ratios for smokers with mucinous tumors increased with increasing pack-years of smoking (OR = 1.0, 1.9, and 2.7 for 24+ pack-years, respectively;P for trend = 0.01) Cigarette smoking appears to be a risk factor for mucinous but not for nonmucinous tumors.