EXPLANATION FOR LONG DURATION OF MYDRIATIC EFFECT OF ATROPINE IN EYE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 15  (8) , 671-673
Abstract
The mydriatic effect of topically applied 3H-atropine (2%) was compared in the pigmented rabbits (black fur and dark brown irides) and nonpigmented (albino) atropinesterase-negative rabbits. The duration t1/2, of the mydriatic effect in the nonpigmented and pigmented rabbit was 43.5 and > 96 h, respectively. At h 96, the tissue 3H-atropine in the pigmented iris was greater than that in the nonpigmented iris by a factor of 8. The longer duration of mydriatic effect in the pigmented iris is explained by the slow release of the bound drug from the pigment to the muscarinic receptors.

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