A Novel Protocol for Construction of Indolylmethyl Group at Aldehydes or Ketones
- 28 August 2001
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2001 (09) , 1403-1406
- https://doi.org/10.1055/s-2001-16808
Abstract
A new method for introduction of indolylmethyl group to aldehydes or ketones using diethyl (o-isocyanophenylmethyl)phosphonate through Horner-Wadsworth-Emmons condensation, thiol-mediated radical cyclization, and the subsequent desulfurization is described. The Horner-Wadsworth-Emmons reagent was prepared from 2-nitrobenzaldehyde in a concise three-step sequence.Keywords
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