Synthesis of Taxol and Taxotere Side Chains by 2-(Trimethylsilyl)thiazole Based Homologation of L-Phenylglycine
- 1 February 1995
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1995 (02) , 181-186
- https://doi.org/10.1055/s-1995-3882
Abstract
L-Phenylglycine is homologated by the use of 2-(trimethylsilyl)thiazole into (2R,3S)-N-benzoyl- and N-tert-butoxycarbonyl-3-phenyl-isoserine, which are isolated as acetonide derivatives in 47 and 35% overall yields and with 84 and 90% ee, respectively.Keywords
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