CHEMOTHERAPEUTIC STUDIES IN THE THIOPHENE SERIES: I. THE SYNTHESIS OF 2-SULPHANILAMIDO-THIOPHENE

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Abstract
A method is described for the synthesis of (1-acetylaminobenzene-4-sulphonamido)-2-thiophene and of (1-aminobenzene-4-sulphonamido)-2-thiophene, also called 2-sulphanilamido-thiophene. The acute toxicity of the above compounds has been determined and an evaluation made of their chemotherapeutic activity in experimental infections of white mice with Pneumococcus Type I; 2-sulphanilamido-thiophene shows no chemotherapeutic activity.

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