Lithiation of 2-Aminoquinoline Derivatives: Functionalization at the 3-Position
- 1 January 1986
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1986 (08) , 670-672
- https://doi.org/10.1055/s-1986-31744
Abstract
2-Pivaloylaminoquinoline (2) undergoes o-lithiation with n-butyllithium to give the intermediate lithio derivative 3. Reaction of 3 with various electrophiles affords 3-substituted 2-pivaloylaminoquinolines 4.Keywords
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