Structural Abnormalities of the Cornea and Lid Resulting from Collagen V Mutations

1 February 2006

journal article
Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science

Vol. 47 (2) , 565-573
https://doi.org/10.1167/iovs.05-0771

Abstract

Purpose. Type V collagen forms heterotypic fibrils with type I collagen and accounts for 10% to 20% of corneal collagen. The purpose of this study was to define the ocular phenotype resulting from mutations in the type V collagen genes COL5A1 and COL5A2 and to study the pathogenesis of anomalies in a Col5a1-deficient mouse.

Keywords

STRUCTURAL ABNORMALITIES
PHENOTYPE RESULTING
DEFICIENT MOUSE
MUTATIONS PURPOSE
LID RESULTING
COLLAGEN FORMS
COL5A1 DEFICIENT

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