Preparation and oxygen binding properties of soluble covalent hemoglobin-dextran conjugates
- 1 August 1981
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 37 (8) , 884-886
- https://doi.org/10.1007/bf01985694
Abstract
Stroma-free hemoglobin solutions present some drawbacks when used as blood substitutes, essentially because the hemoprotein has a low vascular retention, due to its small hydrodynamic volume. Covalent coupling of the protein with dextran derivatives artificially increases its size and affords polymeric conjugates whose oxygen-binding properties (Barcroft's curve, Hill coefficient) depend on the molecular weight.This publication has 6 references indexed in Scilit:
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