Cryothalamectomy for Parkinson's disease

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Abstract
A clinical-statistical evaluation of 1,001 consecutive cryothalamectomles for Parkinson''s disease Is presented, using computer techniques for data processing. One hundred sixty-five variables were extracted from the medical records, Including personal and medical history, preoperatlve findings, and operative and follow-up data. Follow-up data were based on personal elaminations of 203 randomly selected postoperative patients from the original 1,001 cases. The postoperative time range was 5 to 20 months with a mean of 10.6 months. For each of the patients, preoperatlve and Immediate postoperative data was assessed and the overall results, including relief of tremor and rigidity as well as functional status and untoward sequelae, were presented along with the same data for the follow-up series. Second, chi-square analysis delineated the relationship of preoperatlve variables to postoperative results. This demonstrated the effects such variables as age, sex, hypertension, diabetes, cardiac disease, Influenza, encephalitis, pre-operative functional status, autonomic dysfunction, magnitude of symptoms, length of illness, and bilaterallty of disease had on the surgical results and postoperative course, including relief of tremor and rigidity as well as functional status, complications, mortality, recurrence, and length of hospital stay. The statistically significant data are presented In detail, and the implications of the findings are considered.

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