MYOCARDIAL BLOOD FLOW AND OXYGEN CONSUMPTION DURING HALOTHANE-NITROUS OXIDE ANAESTHESIA FOR CORONARY REVASCULARIZATION

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Abstract
The effects of halothane on myocardial blood flow and myocardial O2 balance were studied in 7 male patients with stable angina and normal left ventricular function. Patients were receiving maintenance doses of .beta.-receptor antagonists and underwent coronary artery bypass surgery. Anesthesia consisted of halothane and 50% N2O in O2. Halothane decreased myocardial blood flow and myocardial O2 consumption by 29 and 32%, respectively, after induction of anesthesia, and during sternotomy. Myocardial lactate production was not observed at any time. Cardiac index, stroke volume index, mean arterial pressure and mean diastolic arterial pressure were decreased significantly after induction of anesthesia and during sternotomy. Heart rate remained unchanged. The global myocardial O2 supply and demand relationship was maintained. Evidently halothane is a safe anesthetic for coronary revascularization in patients with unimpaired left ventricular function.