A LONGITUDINAL-STUDY OF PLASMODIUM-FALCIPARUM MALARIA IN THE WEST-AFRICAN SAVANNA USING THE ELISA TECHNIQUE

1 January 1980

journal article
research article

Vol. 58 (3) , 429-438

Abstract

Malarial antibody levels were measured by the enzyme-linked immunosorbent assay (ELISA) in 2 West African populations, one exposed to intense malaria transmission and the other protected. The results reflected the transmission of maternal antibody and in the unprotected population, the subsequent increase of ELISA values with age reflected the development of the immune response to malaria. Malaria control activities reduced ELISA values in the protected population. Numerous infants with previous proven parasitemia were ELISA-negative proving the limitations of this test. Purified antigens are needed to improve the ELISA test for use in serological surveys of malaria.

This publication has 2 references indexed in Scilit:

LONGITUDINAL SEROLOGICAL STUDY OF MALARIA IN INFANTS IN WEST-AFRICAN SAVANNA - COMPARISONS IN INFANTS EXPOSED TO, OR PROTECTED FROM, TRANSMISSION FROM BIRTH
1978
Changing patterns in the humoral immune response to malaria before, during, and after the application of control measures: a longitudinal study in the West African savanna.
1978