Drug Interactions with Quinolones

Publisher Website
Google Scholar
Abstract
The mechanisms involved in drug interactions may be either pharmacokineticor pharmacodynamic. Pharmaco kinetic interactions are the leading events and are caused by alterations in absorption, distribution, metabolism, and elimination of one drug by another. The reported interactions of new quinolones are due to a decrease in antimicrobial activity at low pH, a Mg++-dependent reduction in efficacy, and a probenecid-induced decrease in tubular secretion of ciprofloxacin. The reduction of theophylline clearance by those quinolones that are metabolized primarilyin the liver(enoxacin and ciprofloxacin) isof clinical relevance; also, the interactions of quinolones with Mg++-containing antacids, which result in tremendous loss of bioavailability, are of therapeutic importance.

This publication has 0 references indexed in Scilit: