Basal Oxygen Uptake: A New Technique for an Old Test*

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Abstract
To assess the metabolic effects of T4 and T3, we measured serum total T4 (TT4), free T4 (FT4), total T3 (TT3), TSH, and basal oxygen uptake (VO2) in eight normal subjects in the basal state and after treatment with L-T3 (T3) and sodium ipodate for 2 weeks. T3 treatment resulted in a rise of serum TT3 from a baseline of 137 ± 16 (±SE) to a peak of 239 ± 15 ng/dl. Serum TT4 declined from 8.14 ± 0.56 to 6.08 ± 0.43 μg/dl, FT4 from 1.59 ± 0.13 to 1.03 ± 0.05 ng/dl, and TSH from 1.74 ± 0.24 to 0.56 ± 0.16 /µμU/ml. Basal VO2 increased from 2.66 ± 0.11 to 3.15 ± 0.09 ml/kg·min. Ipodate, on the other hand, led to a lower serum TT3 concentration (102 ± 21 ng/dl), higher serum TT4 and FT4 (9.59 ± 0.5 μg/dl and 1.91 ± 0.13 ng/dl, respectively), and elevated TSH (3.64 ± 0.14 μU/ml). Basal VO2 was reduced to 2.44 ± 0.06 ml/kg · min. Linear regression analysis revealed an excellent positive correlation between serum TT3 and basal VO2 (n = 25; r = 0.747; P < 0.001) and a significant negative correlation between serum TT3 and TSH (n = 26; r =−0.526; P 4 and FT4 correlated negatively with VO2 and positively with serum TSH. The higher T4 level during ipodate treatment was associated with lower VO2 and higher TSH, and vice versa when T4 was suppressed while receiving T3. When ipodate was given concomitantly with T3 to five subjects, only the effects of T3,characterized by increased VO2 and decreased TSH, were evident. These data indicate that both basal VO2 and serum TSH are sensitiveindices of thyroid hormone activities. The latter gives only the directional change (hyper- or hypothyroidism), while the former more accurately quantitates the magnitude of the derangement. Moreover, it appears that in man, T3, and not T4, is the primary hormone thatregulates thermogenesis and TSH secretion.

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