Diastereoselective addition of lithiated N,N-diethyl-o-toluamide to chiral isopropylidine glyceraldehyde lmines. Asymmetric synthesis of 3-substituted 3,4-dihydro-1(2H)-isoquinolones
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 14,p. 930-931
- https://doi.org/10.1039/c39890000930
Abstract
The lithio derivative of N,N-diethyl-o-toluamide adds regiospecifically to (R)-and (S)-glyceraldehyde acetonide p-methoxybenzyl imines to afford the Cram-chelation controlled products (3S,1′R)-(3) and (3R,1′S)-(3),respectively.Keywords
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