Local Glycosaminoglycan Polysulphate Injection Therapy in Osteoarthritis of the Hand
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 17 (3) , 197-202
- https://doi.org/10.3109/03009748809098782
Abstract
In this placebo-controlled double-blind trial in 30 patients suffering from disabling osteoarthritis of the hand, the long-term effect of periarticular injections of glycosaminoglycan polysulphate (GAGPS) on symptoms, hand function and life quality was investigated. The overall effect of the half-year follow-up was clinically good in 46% of the GAGPS-treated cases, compared with 14% of the controls. Significant differences in grip- and pinch strength were also found between the treatment groups. Significant differences were still seen at the one-year follow-up, as 13 patients (87%) in the GAGPS group reported improvement in their most restricted activity, compared with 6 (43%) of the controls. Nine periarticular injections of GAGPS over a period of 13 weeks gave a clinically good and long-lasting effect, with improved life quality for most of the patients.This publication has 6 references indexed in Scilit:
- Articular Cartilage Breakdown in a Lapine Model of OsteoarthritisPublished by Wolters Kluwer Health ,1986
- THE EFFECT OF GLYCOSAMINOGLYCAN POLYSULFURIC ACID ESTER ON ARTICULAR-CARTILAGE IN EXPERIMENTAL OSTEOARTHRITIS - EFFECTS ON MORPHOLOGICAL VARIABLES OF DISEASE SEVERITY1986
- Arthroplasty of the Thumb Basal JointsPublished by Wolters Kluwer Health ,1985
- Osteoarthritis in the handThe Journal of Hand Surgery, 1983
- Glycosaminoglycan Polysulphate Treatment in Experimental Osteoarthritis in RabbitsScandinavian Journal of Rheumatology, 1983
- Another look at osteoarthritis.Annals of the Rheumatic Diseases, 1979