Acute target organ toxicity of 1‐nitronaphthalene in the rat

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Abstract
1‐Nitronaphthalene (1‐NN) produced respiratory distress and centrilobular liver necrosis in male Sprague‐Dawley rats after a single intraperitoneal injection (100 mg kg−1). Microscopic examination of the lungs of rats killed 24 h after the injection revealed a highly selective non‐ciliated bronchiolar (Clara) cell necrosis as the only remarkable lesion. Pretreatment of animals with phenobarbital offered complete protection from the respiratory distress induced by 1‐NN, but increased the severity of the hepatotoxicity. Pretreatment with SKF‐525A protected against 1‐NN‐induced liver necrosis, but did not alter the incidence or severity of the respiratory distress. Under similar conditions, this pattern of toxicity was not seen with the structural analogue 2‐nitronaphthalene.