Effects of gastrointestinal hormones and their related compounds on gastric motility in the rat.

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Abstract
We examined the effects of certain gastrointestinal hormones on gastric motility using rat stomach preparations in vivo. Changes of water level caused by the movement of the stomach which was filled with saline were recorded. Single injections of cholecytokinin (1, 2 and 4 .mu.g/kg) induced relaxation of the stomach. Single injections of bombesin in low doses (below 0.2 .mu.g/kg) induced relaxation and in high doses (over 0.2 .mu.g/kg) contraction after brief relaxation. Single injections of neurotensin (1, 2, 4 and 8 .mu.g/kg), somatostatin (5, 10 and 20 .mu.g/kg) and substance P (1, 2, 4 and 8 .mu.g/kg) induced relaxation followed by contraction, but their dose-response relations were obscure. Infusions of neurotensin (1, 5 and 25 .mu.g/kg/h) and somatostatin (2.5 and 5 .mu.g/kg/h) enhanced the stomach tension, whereas substance P (1, 5 and 25 .mu.g/kg/h) reduced it. Single injections and infusions of neurotensin, somatostatin or substance P showed different effects on gastric motility. On the other hand, Met-enkephalin (1, 10 and 100 .mu.g/kg) and porcine motilin (1, 10 and 100 .mu.g/kg) did not affect gastric motility in our rat stomach preparations. These results suggest that some gastrointestinal hormones take part in stomach movements.

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