Mapping of the Structural Genes of the Three Aspartokinases and of the Two Homoserine Dehydrogenases of Escherichia coli K-12
- 1 January 1974
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 117 (1) , 133-143
- https://doi.org/10.1128/jb.117.1.133-143.1974
Abstract
Mutants requiring threonine plus methionine (or homoserine), or threonine plus methionine plus diaminopimelate (or homoserine plus diaminopimelate) have been isolated from strains possessing only one of the three isofunctional aspartokinases. They have been classified in several groups according to their enzymatic defects. Their mapping is described. Several regions of the chromosome are concerned: thrA (aspartokinase I-homoserine dehydrogenase I) is mapped in the same region as thrB and thrC (0 min). lysC (aspartokinase III) is mapped at 80 min, far from the other genes coding for diaminopimelate synthesis. metLM (aspartokinase II-homoserine dehydrogenase II) lies at 78 min closely linked to metB, metJ , and metF .Keywords
This publication has 27 references indexed in Scilit:
- The Threonine‐Sensitive Homoserine Dehydrogenase and Aspartokinase Activities of Escherichia coli K12European Journal of Biochemistry, 1972
- Revised Structure of Aspartokinase I‐Homoserine Dehydrogenase I of Escherichia coli K12European Journal of Biochemistry, 1972
- The sequence of four structural and two regulatory methionine genes in theSalmonella typhimuriumlinkage mapGenetics Research, 1968
- Selection of Escherichia coli mutants devoid of one or of both the activities carried by a multifunctional proteinBiochemical and Biophysical Research Communications, 1968
- Regulation by methionine of the synthesis of third aspartokinase and of a second homoserine dehydrohenase in Escherichia coli K 12Biochimica et Biophysica Acta (BBA) - General Subjects, 1967
- Subunits of the complex protein carrying the threonine-sensitive aspartokinase activity in a mutant ofBiochemical and Biophysical Research Communications, 1967
- Early changes of hexose monophosphate pathway activity and of NADPH oxidation in phagocytizing leucocytesBiochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation, 1965
- Optimal conditions for mutagenesis by N-methyl-N′-nitro-N-nitrosoguanidine in escherichia coli K12Biochemical and Biophysical Research Communications, 1965
- Rétro-inhibition et répression de l'homosérine déshydrogénase d'Escherichia coliBiochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects, 1963
- Multivalent repression in the biosynthesis of threonine in Salmonella, typhimurium and Escherichia, coliBiochemical and Biophysical Research Communications, 1963